Treatment Recommendations

The first edition of the African Antibiotic Treatment Guidelines provide antimicrobial treatment recommendations, principles of stewardship, and other clinical guidance for the following bacterial syndromes:


Central Nervous System


Acute Bacterial Meningitis (Community-Acquired) | Adult | Neonatal/Pediatric


Head, Eye, Ear, Nose & Throat


Acute Purulent Neonatal Conjunctivitis | Neonatal/Pediatric

Acute Otitis Media | Adult | Neonatal/Pediatric

Bacterial Pharyngotonsillitis | Adult | Neonatal/Pediatric

Suspected Acute Bacterial Sinusitis | Neonatal/Pediatric

Dental Abscess | Adult | Neonatal/Pediatric




Acute Rheumatic Fever | Neonatal/Pediatric

Infective Endocarditis | Adult | Neonatal/Pediatric




Acute Bronchitis | Adult

Acute Exacerbation of COPD | Adult

Acute Lower Respiratory Tract Infection (Community-Acquired)


Severe/Inpatient | Neonatal/Pediatric


Community-Acquired Mild to Moderate, in Ambulatory Outpatients  | Adult

Community-Acquired Severe, for Hospitalized Patients | Adult

Hospital-Acquired (Nosocomial) Pneumonia (HAP) | Adult




Acute Diarrhoeal Disease| Adult | Neonatal/Pediatric

Complicated Intra-Abdominal Infection (Community-Acquired) | Adult | Neonatal/Pediatric

Typhoid/Enteric Fever| Adult | Neonatal/Pediatric




Acute Pyelonephritis | Adult

Mild to Moderate Acute Uncomplicated Prostatitis| Adult

Urinary Tract Infection (UTI) | Adult | Neonatal/Pediatric

Syphilis (Including congenital syphilis) | Neonatal/Pediatric


Skin, Soft Tissue, Bone & Joints


Skin & Soft Tissue Infections | Adult | Neonatal/Pediatric

Tetanus| Neonatal/Pediatric

Acute Osteomyelitis & Septic Arthritis| Adult | Neonatal/Pediatric




Sepsis in the Newborn| Neonatal/Pediatric

Possible Serious Bacterial Infection in infants younger than 3 months of age (Community-Acquired) | Neonatal/Pediatric

Sepsis (Septicemia) & Septic Shock | Adult


Download the Complete Guidelines